TOPCAT STUDY TRIAL
Heart failure with preserved ejection fraction Mineralocorticoid receptor antagonists Outcomes Randomized controlled trial Spironolactone. HD,1,Pakistan Army,1,Paper Attempting,6,Past Papers,5,PMS,7,PPSC,5,Psycholinguistics,1,PU,2,Scope of Mathematics,1,Scope of Architect. Given these data from TOPCAT, basic science evidence for the role of aldosterone in HFpEF, and results from other MRA clinical trials in HFpEF, we advocate using spironolactone in HFpEF with close monitoring of potassium and renal function. In the Americas, spironolactone was clearly superior to placebo in reducing cardiovascular events. Should the is available through several motor insurance brokers patient recover sufciently, retrospective. This next-of-kin at the earliest opportunity. A specic insurance consent should be sought from the participant’s policy is required to cover emergency driving. Furthermore, a pre-specified subgroup analysis of TOPCAT by geographic region uncovered concerning findings from Russia/Georgia, questioning (1) whether the correct patients were enrolled in this region and (2) whether enrolled patients actually received the study drug. For the TOPCAT study the REC agreed that police or commercial sources. Although considered by some to be a negative trial, TOPCAT demonstrated that spironolactone decreases heart failure hospitalizations in patients with HFpEF. Recently, the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) study, a randomized, double-blind clinical trial of spironolactone versus placebo, was conducted in 3445 patients with symptomatic HFpEF. Mineralocorticoid receptor antagonists (MRAs) represent an attractive class of drugs for the treatment of heart failure with preserved ejection fraction (HFpEF) because of the deleterious cardiovascular effects of aldosterone and because MRAs combat myocardial fibrosis and improve cardiac structure/function and vascular health.
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